Charles Jules Henry Nicole
Charles Jules Henry Nicole
appears duration fever five follows pattern period
I demonstrated the characteristics of experimental fever. It appears after an incubation period which is never less than five days. It follows the same pattern as natural fever in man, but is of shorter duration and less pronounced.
contagion knew urgent
Of all the problems which were open to me for study, typhus was the most urgent and the most unexplored. We knew nothing of the way in which contagion spread.
guinea infection possible preserve soon third virus year
The discovery that I soon made that the guinea pig was also susceptible to infection made it possible for me, from the third year on, to preserve the virus on this animal.
infection
I finally demonstrated that typhus infection is not hereditary in the louse.
guinea infection pig point practical preserving proved step useful
From the practical point of view, the susceptibility to infection of the guinea pig proved to be the most useful step forward. Today, all laboratories use this animal for preserving the virus.
attempts easily including laboratory smaller species supply transmit
My first attempts to transmit typhus to laboratory animals, including the smaller species of monkeys, had failed, as had those of my predecessors, for reasons which I can easily supply today.
contacts fortunate soon spite
The fact that I was fortunate enough to escape contagion, in spite of frequent, sometimes daily contacts with the disease, was because I soon guessed how it spread.