Alison Goate
Alison Goate
disease few form found genes increase risk
There are a few genes that have been implicated in the development of early-onset Alzheimer's disease, but other than APOE, no genes have been found that increase risk for the more common, late-onset form of the disease.
consistent disease dna evidence factor four gene identified region results risk seen series since study variant
The region of DNA identified in our study showed evidence of replication in four independent series of experiments. I haven't seen a putative risk factor show such consistent results since the e4 variant of the APOE gene was identified as a risk factor for late-onset Alzheimer's disease more than 10 years ago.
cluster genes looked noticed region taste
We looked in a region of chromosome 7, where there are hundreds of genes, and we noticed that there was a cluster of taste receptor genes in this region.
environmental factors genes highest influence predict prevention risk strategies target understand
When we understand more about the genes and the environmental factors that influence someone's risk, I think you will be better able to predict who is at highest risk and then target your prevention strategies at those high-risk individuals.