Donald Berry
Donald Berry
advantage open practical seem
There does seem to be a statistical advantage, but the practical advantage is still an open question.
anathema based depending design determine disease doctors exploits last multiple ongoing patient potential responding results standard study treatment trials using
Doctors want to be able to design trials to look at multiple potential treatment combinations and use biomarkers to determine who is responding to what medication. At the end of the day, when they enroll the last patient in the study they want to be able to treat that patient optimally depending on the patient's disease characteristics. Using a Bayesian approach, the trial design exploits the results as the trial is ongoing and adapts based on these interim results. That kind of thing is an anathema in the standard approach.