Eric Nestler
Eric Nestler
animal induced learn process production respond reward social stimulus
The social-defeat process induced production of BDNF in the reward circuit. Without BDNF in the circuit, an animal can't learn that a social stimulus is threatening and respond accordingly.
brain changes chronic effects existing insight provides stress study triggers
Our study provides insight into how chronic stress triggers changes in the brain that are much more long-lived than the effects of existing antidepressants.
behavioral both removal treatment
Removal of BDNF before bullying, or treatment with antidepressants after bullying, both removed the behavioral abnormality observed.
actions analysis level molecular points potential provides regions study treatments understand
Our study provides a fundamentally new level of analysis by which we can better understand the actions of cocaine in brain-reward regions at the molecular level. It also points to new potential treatments for addiction.
abuse addiction brain cardinal cause changes features field key last mechanisms question
One of the cardinal features of addiction is how long-lived it is, ... A key question in the field has been: By what mechanisms do drugs of abuse cause changes in the brain that last this long?
chronic cure easily elsewhere induced molecular perhaps remove scar stress treatments
The molecular scar induced by chronic stress in the hippocampus, and perhaps elsewhere in the brain, can't be easily reversed. To really cure depression, we probably need to find new treatments that can remove the silencer molecules.