Per Svenningsson
Per Svenningsson
Per Svenningsson is a neurologist specializing in the neuropharmacology of movement disorders such as Parkinson’s disease. He is a professor of neurology at the Department of Clinical Neuroscience at the Karolinska Institutet and in the Department of Neurology at Karolinska University Hospital in Stockholm, Sweden. He is the team leader of a research group that studies the underlying pathogenic process of PD. Svenningsson is also a member of many research councils and committee, including the European College of Neuropsychopharmacology...
additional fewer future side target turn
It may turn out that future antidepressants could target this 5-HT receptor, and probably some additional 5-HT receptors, but not necessarily all 5-HT receptors. Hopefully, such antidepressants will have fewer side effects.
achieve action addition class depressed develop exploring increase mimic possible ways
In addition to exploring ways to increase p11 in depressed patients, it may also be possible to develop peptide-based compounds that can mimic the action of p11 to achieve a new class of anti-depressant compounds.
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We have shown that a gene called p11 is involved in the multiple complex changes that underlie depression. Our findings demonstrate that patients with depression, and mice that model this disease, have decreased levels of p11 protein, and they suggest that drugs that increase p11 are likely to have anti-depressant properties.
changes complex gene involved multiple shown
We have shown that a gene (or protein) called p11 is involved in the multiple complex changes that underlie depression.